Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromo-3-phenyl-1H-pyrazol-5-amine → 3-[[(4-bromo-5-phenyl-1H-pyrazol-3-yl)amino]methylidene]-4-methyl-1H-indol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromo-3-phenyl-1H-pyrazol-5-amine | HCID 594319 | — |
| 반응물 | HCID 178418806 | HCID 178418806 | — |
| 반응물 | HCID 178423596 | HCID 178423596 | — |
| 반응물 | HCID 178517101 | HCID 178517101 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-[[(4-bromo-5-phenyl-1H-pyrazol-3-yl)amino]methylidene]-4-methyl-1H-indol-2-one | HCID 178423595 | — |
반응 단계
The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 4-bromo-5-phenyl-1H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one (0.1622 gms.) is reacted with 0.4530 gms. of 4-bromo-5-phenyl-1H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (3.0 mL).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06559173B1 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-60f37002e36a4a62a973846351568cc2 |
| 출처 메모 | uspto-grants-2003_05 |