Hydrazine → HCID 178489814, 화합물

HRID 411699

반응식

HRID 411699 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9](=O)[CH2:10][C:11]#[N:12])[CH:6]=[CH:7][CH:8]=1.[NH2:14][NH2:15]>CCO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([NH2:12])[NH:14][N:15]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 5847163-(3-Methoxyphenyl)-3-oxopropanenitrile

생성물 1

HCID 178489814HCID 178489814, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3-(3-Methoxy-phenyl)-3-oxo-propionitrile (2.0202 gms.) is then suspended in 55 mL of anhydrous EtOH. This suspension is treated with 0.73 mL of anhydrous hydrazine and subsequently heated to refluxing temperature for 1 day. The reaction mixture is concentrated in vacuo. The residue is then triturated with isopropanol to precipitate out the 5-(3-methoxy-phenyl)-2H-pyrazol-3-ylamine as a white solid.

후처리

  1. temperaturesubsequently heated
  2. temperatureto refluxing temperature for 1 day
  3. concentrationThe reaction mixture is concentrated in vacuo
  4. customThe residue is then triturated with isopropanol
  5. customto precipitate out the 5-(3-methoxy-phenyl)-2H-pyrazol-3-ylamine as a white solid

출처 및 근거

ORD 기록
ord-7a04ae81653d45c083f1248453501ccf
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559173B1

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