Sodium Bicarbonate → HCID 9851675, 화합물

HRID 411773노트

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HRID 411773 반응식
F[C:2](F)(F)[C:3]([OH:5])=[O:4].[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]2[C:19](=[O:47])[N:20]([CH2:37][O:38][C:39]([CH:41]3[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]3)=[O:40])[C:21](=[O:36])[C:22]=2[C:23]2[C:31]3[C:26](=[CH:27][C:28]([N+:32]([O-:34])=[O:33])=[CH:29][CH:30]=3)[N:25]([CH3:35])[CH:24]=2)=[CH:10]1.C([O-])(O)=O.[Na+]>C(OCC)(=O)C>[C:3]([OH:5])(=[O:4])[CH3:2].[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]2[C:19](=[O:47])[N:20]([CH2:37][O:38][C:39]([CH:41]3[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]3)=[O:40])[C:21](=[O:36])[C:22]=2[C:23]2[C:31]3[C:26](=[CH:27][C:28]([N+:32]([O-:34])=[O:33])=[CH:29][CH:30]=3)[N:25]([CH3:35])[CH:24]=2)=[CH:10]1

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 69945384HCID 69945384, 화합물

생성물 1

HCID 9851675HCID 9851675, 화합물수율 97%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Piperidine-4-carboxylic acid 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-pyrrol-1-ylmethyl ester trifluoroacetate, prepared as in example 8a above, was dissolved in ethyl acetate. The resulting solution was neutralized with cold saturated NaHCO3. The ethyl acetate layer was concentrated and slurried in H2O and acidified with excess HOAc and lyophilized to give the desired product (yield—97%).

후처리

  1. concentrationThe ethyl acetate layer was concentrated and slurried in H2O

출처 및 근거

ORD 기록
ord-b0edc6bffe5648f4be3317a0bdda8d7b
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559164B1

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