Sulfuric Acid → 5-Chlorohexanoic acid

HRID 411801

반응식

HRID 411801 반응식
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[Cl:9]N(C(C)C)C(C)C.S(=O)(=O)(O)O>>[Cl:9][CH:5]([CH3:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:8])=[O:7]

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 8892Hexanoic AcidHCID 32745N-Chloro-N,N-diisopropylamine

생성물 1

HCID 185416685-Chlorohexanoic acid

실험 절차

147 parts by mass of the obtained caproic acid and an equivalent amount of N-chlorodiisopropylamine were added to 1,000 parts by mass of 84% sulfuric acid and were reacted for 5 hours at 25° C. to obtain 177 parts by mass of 5-chlorocaproic acid. Then 177 parts by mass of the 5-chlorocaproic acid were boiled with an aqueous solution of an equivalent amount of sodium hydroxide to obtain 129 parts by mass of δ-caprolactone. The 13C-NMR (100 MHz, TMS, CDCl3) of the synthesized δ-caprolactone was measured to obtain the following δ values: 19.90 ppm, 20.88 ppm, 34.27 ppm, 35.31 ppm, 70.44 ppm and 172.84 ppm.

후처리

  1. customwere reacted for 5 hours at 25° C.

출처 및 근거

ORD 기록
ord-45f75b5187b74797b2ffbb03367df60c
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559275B2

연결된 노트

불러오는 중…