405271-20-7 → 325793-74-6

HRID 411878노트

반응식

HRID 411878 반응식
[CH2:1]([O:3][C@@H:4]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16]CC2C=CC=CC=2)=[CH:12][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6])[CH3:2]>CO.[C].[Pd]>[CH2:1]([O:3][C@@H:4]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6])[CH3:2]

참가 물질

4

반응물 1

HCID 12087759405271-20-72회

생성물 1

HCID 10176889325793-74-6수율 96%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

A mixture of (S)-methyl 2-ethoxy-3-(4-benzyloxyphenyl)propanoate of the formula (9c) (56 g) in aqueous methanol (300 ml) and slurry of 5% palladium carbon (6 g in 60 ml water) was taken in hydrogenation flask and hydrogenated on Parr shake flask at 60 psi pressure for 6-8 h at room temperature. Completion of the reaction was monitored by TLC. After completion of the reaction, the catalyst was filtered and the filtrate was evaporated to yield tile compound of the formula (1) (39 g, 96%).

후처리

  1. customAfter completion of the reaction
  2. filtrationthe catalyst was filtered
  3. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-ef117fd157c348dda8a35db025a03fec
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559335B2

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