Sodium Iodide → N-[3-(iodoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester

HRID 4119노트

반응식

HRID 4119 반응식
Br[CH2:2][C:3]([N:5]1[CH2:9][CH2:8][N:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[C:6]1=[O:18])=[O:4].[I-:19].[Na+]>CC(C)=O>[I:19][CH2:2][C:3]([N:5]1[CH2:9][CH2:8][N:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[C:6]1=[O:18])=[O:4]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 57105682N-[3-(Bromoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester

생성물 1

HCID 57241819N-[3-(iodoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

N-[3-(Bromoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester (20.9 g, 65 mmol) was dissolved in acetone (250 ml) containing sodium iodide (10.5 g, 70 mmol). The solution was stirred at reflux for three hours and filtered hot through Celite. The solution was evaporated in vacuo to give the title compound as a light yellow solid, 23.9 g.

후처리

  1. temperatureat reflux for three hours
  2. filtrationfiltered hot through Celite
  3. customThe solution was evaporated in vacuo

출처 및 근거

ORD 기록
ord-71dd9c746bed41b09c643f7528bb9407
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723002

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