Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,5-Dichloro-2-fluoroaniline → 4-[(3,4-Dichloro-6-fluorophenyl)amino]-6-nitroquinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,5-Dichloro-2-fluoroaniline | HCID 223091 | — |
| 반응물 | 4-Chloro-6-nitroquinazoline | HCID 11356257 | — |
| 생성물 | 4-[(3,4-Dichloro-6-fluorophenyl)amino]-6-nitroquinazoline | HCID 15480998 | — |
반응 단계
In one particular, 3,4-dichloro-6-fluoroaniline is reacted with 4-chloro-6-nitroquinazoline, so as to produce 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-nitroquinazoline, which is reduced, by means of an ethanolic solution of hydrazine hydrate and Raney®Nickel, so as to produce 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-aminoquinazoline. Then, the 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-aminoquinazoline is reacted with a carbon-11 labeled acryloyl chloride so as to produce a carbon-11 labeled {4-[(3,4-dichloro-6-fluorophenyl)amino]quinazoline-6-yl]acrylamide (radiolabeled Compound 3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06562319B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-01f954d9b7ed424a880d8c81650992e5 |
| 출처 메모 | uspto-grants-2003_05 |