Aniline → 6-Nitro-N-phenylquinazolin-4-amine

HRID 411945

반응식

HRID 411945 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([N+:19]([O-:21])=[O:20])[CH:17]=2)[N:12]=[CH:11][N:10]=1>C(O)(C)C>[C:2]1([NH:1][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([N+:19]([O-:21])=[O:20])[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6115Aniline2회HCID 113562574-Chloro-6-nitroquinazoline

생성물 1

HCID 53281896-Nitro-N-phenylquinazolin-4-amine

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Aniline or derivatized aniline (1 equivalent) is reacted with 4-chloro-6-nitroquinazoline (3.5 equivalents), in a polar solvent such as iso-propylalcohol. The product, 4-(phenylamino)-6-nitroquinazoline, is obtained after filtration.

출처 및 근거

ORD 기록
ord-9f799eb6e18641d0b816532f9a5df4f8
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06562319B2

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