참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzene, 1-iodo-4-(trifluoromethyl)- | HCID 67993 | — |
| 반응물 | 1,4-Tetrahydrothiazine-3-one | HCID 88402 | — |
| 촉매 | Copper | HCID 23978 | — |
| 생성물 | 4-(4-Trifluoromethylphenyl)-thiomorpholin-3-one | HCID 12083010 | 23.3% |
반응 단계
A mixture of thiomorpholin-3-one (500 mg, 4.27 mmol), 4-trifluoromethyl-1-iodobenzene (1.25 mL, 8.5 mmol) and copper metal (814 mg, 12.8 mmol) was heated in a sealed glass tube at 185-200° C. for 18 hours. The residue was then purified by flash chromatography to give 260 mg of the title product as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06562813B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_05 |
|---|
| ORD ID | ord-ad8e8f21d3844c8da18ab3779257a5e3 |
|---|
| 출처 메모 | uspto-grants-2003_05 |
|---|
