Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Aniline → 1-(Phenylamino)butan-2-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | 1,2-Epoxybutane | HCID 7834 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | Potassium Fluoride | HCID 522689 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(Phenylamino)butan-2-ol | HCID 14072197 | — |
반응 단계
Aniline, (102.3 g, 1.1 mole) was added to 50 ml of dioxane, 108 g of 1,2-epoxy butane and 1 g of potassium fluoride in 25 ml of water. The mixture heated to reflux for 30 hours. The mixture was poured into water, taken up in 200 ml of methylene chloride, dried over anhydrous magnesium sulfate and stripped under vacuum. The residue was distilled under vacuum and the product, b.p. 98°-106° C. at 0.15 mm, weighed 94 g and was 97% pure by GLPC. It was characterized by IR and NMR.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04723986 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-81dc0c6c46c04f688c9e0a0ed9716418 |
| 출처 메모 | uspto-grants-1988_02 |