trans-Ethyl 3-(4-cyano-3-fluorophenyl)-2-propenoate → Ethyl 4-cyano-3-fluorophenylpropanoate

HRID 412192노트

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HRID 412192 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[CH:10]/[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5][C:4]=1[F:16])#[N:2]>CO.[Pd]>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5][C:4]=1[F:16])#[N:2]

참가 물질

4

반응물 1

HCID 23021829trans-Ethyl 3-(4-cyano-3-fluorophenyl)-2-propenoate

생성물 1

HCID 18536111Ethyl 4-cyano-3-fluorophenylpropanoate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of the product from Step B (1.3 g, 5.9 mmol) in 30 mL of methanol was added 10% palladium on carbon (130 mg). The solution was stirred at room temperature under an atmosphere of hydrogen for 2 hours, then purged with argon. The mixture was filtered through celite, the filter pad was washed with methanol, and the filtrate was concentrated in vacuo. The crude product was purified on a C18 preparative HPLC column to give the titled product after conversion to the free base.

후처리

  1. custompurged with argon
  2. filtrationThe mixture was filtered through celite
  3. washthe filter pad was washed with methanol
  4. concentrationthe filtrate was concentrated in vacuo
  5. customThe crude product was purified on a C18 preparative HPLC column

출처 및 근거

ORD 기록
ord-5c5b2f468a4446d6b5f3a3c1ffad90d1
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06562823B1

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