Dichloromethane → 2-Isopropoxyethyl Methanesulfonate

HRID 41233

반응식

HRID 41233 반응식
ClCCl.[CH:4]([O:7][CH2:8][CH2:9][OH:10])([CH3:6])[CH3:5].C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C(OCC)(=O)C.O>[CH3:18][S:19]([O:10][CH2:9][CH2:8][O:7][CH:4]([CH3:6])[CH3:5])(=[O:21])=[O:20]

참가 물질

7

반응물 4

HCID 6344DichloromethaneHCID 7996IsopropylethanediolHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

생성물 1

HCID 184650452-Isopropoxyethyl Methanesulfonate

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

To a dichloromethane (50 mL) mixture of 2-isopropoxyethanol (5.21 g, 50.0 mmol) and triethylamine (7.70 mL, 55.0 mmol), was added methanesulfonyl chloride (4.30 mL, 55.0 mmol) while stirring on ice, and the resulting mixture was stirred for 30 minutes. Water and ethyl acetate were added to the mixture. After the mixture was thoroughly shaken, the organic layer was separated, and the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The mixture was filtered, and the solvent in the filtrate was then distilled off under reduced pressure.

후처리

  1. stirringthe resulting mixture was stirred for 30 minutes
  2. stirringAfter the mixture was thoroughly shaken
  3. customthe organic layer was separated
  4. washthe organic layer was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationThe mixture was filtered
  7. distillationthe solvent in the filtrate was then distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-2d7de98408074f379c8ba234f78ceff7
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530504B2

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