Dichloromethane → 3-Methoxybutyl methanesulfonate

HRID 41235

반응식

HRID 41235 반응식
ClCCl.[CH3:4][O:5][CH:6]([CH3:10])[CH2:7][CH2:8][OH:9].C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C(OCC)(=O)C.O>[CH3:18][S:19]([O:9][CH2:8][CH2:7][CH:6]([O:5][CH3:4])[CH3:10])(=[O:21])=[O:20]

참가 물질

7

반응물 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 172913-Methoxy-1-butanolHCID 31297Methanesulfonyl chloride

생성물 1

HCID 145340313-Methoxybutyl methanesulfonate

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

To a dichloromethane (30 mL) mixture of 3-methoxy-1-butanol (3.12 g, 30.0 mmol) and triethylamine (4.62 mL, 33.0 mmol), was added methanesulfonyl chloride (4.62 mL, 33.0 mmol) while stirring on ice, and the mixture was stirred at room temperature for 30 minutes. To the mixture, were added water and ethyl acetate. After thoroughly shaking the mixture, the organic layer was separated, and the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The mixture was then filtered, and the solvent in the filtrate was then distilled off under reduced pressure.

후처리

  1. stirringthe mixture was stirred at room temperature for 30 minutes
  2. stirringAfter thoroughly shaking the mixture
  3. customthe organic layer was separated
  4. washthe organic layer was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationThe mixture was then filtered
  7. distillationthe solvent in the filtrate was then distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-e0b3177f9ddd4c4a82de19eb17756366
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530504B2

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