1-(Pyridin-4-yl)piperidine-4-carbamic acid benzyl ester → 1-(Pyridin-4-yl)piperidin-4-amine

HRID 412623노트

반응식

HRID 412623 반응식
C(OC(=O)[NH:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[NH2:10][CH:11]1[CH2:12][CH2:13][N:14]([C:17]2[CH:18]=[CH:19][N:20]=[CH:21][CH:22]=2)[CH2:15][CH2:16]1

참가 물질

4

반응물 1

HCID 600641081-(Pyridin-4-yl)piperidine-4-carbamic acid benzyl ester

생성물 1

HCID 189186081-(Pyridin-4-yl)piperidin-4-amine수율 99.9%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

1-(Pyridin-4-yl)piperidine-4-carbamic acid benzyl ester (9.46 g) was hydrogenated using 7.5% palladium carbon (3.57 g) in ethanol (95 ml) solution at 3 atm over 3 hours. After completion of the reaction, the reaction mixture was filtered through celite, and the solvent was evaporated and the residue was dried under reduced pressure to give the title compound (5.38 g).

후처리

  1. customover 3 hours
  2. customAfter completion of the reaction
  3. filtrationthe reaction mixture was filtered through celite
  4. customthe solvent was evaporated
  5. customthe residue was dried under reduced pressure

출처 및 근거

ORD 기록
ord-8d081c17604143c885296a33b2179a5f
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06562828B1

반응 노트

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