참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Beta-Alanine | HCID 239 | — |
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | Phosphorus trichloride | HCID 24387 | — |
| 반응물 | Phosphorous acid | HCID 107909 | — |
| 생성물 | Pamidronic Acid | HCID 4674 | — |
반응 단계
The mixture of 5 eq. phosphorous acid and β-alanine is heated to form a melt. Morpholine (1 eq.) is slowly added. The reaction is cooled to about 70° C. and 2 eq. of PCl3 are added. The mixture is heated for about 3.5 hours. Then the reaction is hydrolyzed in aqueous acid at about 75° C. for about 0.5 hours. Crystallization from aqueous acid/IPA, affords pamidronate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06562974B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_05 |
|---|
| ORD ID | ord-1073b756d7524ebf91ed74ed69b1f293 |
|---|
| 출처 메모 | uspto-grants-2003_05 |
|---|
