참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Gamma-Aminobutyric Acid | HCID 119 | — |
| 반응물 | Phosphorus trichloride | HCID 24387 | — |
| 반응물 | Phosphorous acid | HCID 107909 | — |
| 생성물 | Alendronic Acid | HCID 2088 | — |
반응 단계
The mixture of 5 eq. phosphorous acid, 4-aminobutyric acid and morpholine. HCl is melted together until uniform solution is formed. The reaction mixture is cooled to about 70° C. and 2 eq. of PCl3 are carefully added. The mixture is heated for about 5.5 hours before the reaction mixture is hydrolyzed in aqueous acid at about 80° C. and alendronate is isolated from an ethanolic solution.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06562974B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_05 |
|---|
| ORD ID | ord-b3a0f7fd2bd7403f9357ce99aee0cb71 |
|---|
| 출처 메모 | uspto-grants-2003_05 |
|---|
