Ammonia → 2,3,5-Trifluoro-6-nitroaniline

HRID 412726

반응식

HRID 412726 반응식
F[C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[C:4]([F:10])[C:3]=1[N+:11]([O-:13])=[O:12].[NH3:14].O1CCOCC1>O>[F:8][C:7]1[C:6]([F:9])=[CH:5][C:4]([F:10])=[C:3]([N+:11]([O-:13])=[O:12])[C:2]=1[NH2:14]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 312751,4-DioxaneHCID 675661,2,3,5-Tetrafluoro-4-nitrobenzene

생성물 1

HCID 2230852,3,5-Trifluoro-6-nitroaniline수율 51%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution comprising 2,3,4,6-tetrafluoronitrobenzene (0.6 g, 3.1 mmol) and ammonia in dioxane (Aldrich, 0.5M, 7.5 mmol) was stirred at room temperature for 3 hours to give a fine white precipitate. The mixture was diluted with an equal volume of water to dissolve the white precipitate and give yellow crystals. The crystals were isolated were collected and dried to provide 2,3,5-trifluoro-6-nitroaniline (307 mg, 51%) as yellow needles; m.p. 66° C.; 1H NMR (CDCl3) δ 6.4 (1H, m), δ 6.0 (2H, s).

후처리

  1. customto give a fine white precipitate
  2. dissolutionto dissolve the white precipitate
  3. customgive yellow crystals
  4. customThe crystals were isolated
  5. customwere collected
  6. customdried

출처 및 근거

ORD 기록
ord-63bd390fc9ae4e0e94c0a4d53118d5a4
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06562854B2

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