2,3,5-Trifluoro-6-nitroaniline → 3,4,6-Trifluorobenzene-1,2-diamine

HRID 412727

반응식

HRID 412727 반응식
[F:1][C:2]1[C:8]([F:9])=[CH:7][C:6]([F:10])=[C:5]([N+:11]([O-])=O)[C:3]=1[NH2:4]>[Pd].C(O)C>[NH2:11][C:5]1[C:6]([F:10])=[CH:7][C:8]([F:9])=[C:2]([F:1])[C:3]=1[NH2:4]

참가 물질

4

반응물 1

HCID 2230852,3,5-Trifluoro-6-nitroaniline

생성물 1

HCID 5956243,4,6-Trifluorobenzene-1,2-diamine수율 87%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 2,3,5-trifluoro-6-nitroaniline (300 mg, 1.56 mmol) and 10% palladium on carbon in absolute ethanol was hydrogenated overnight at atmospheric pressure, filtered under nitrogen and concentrated to provide 1,2-diamino-3,4,6-trifluorobenzene (219 mg, 87% yield) as a purple crystalline solid; MS M+ 162.7, +41. +82 (+ACN, +2ACN). (calcd for C6H5F3N2: 162.11).

후처리

  1. filtrationfiltered under nitrogen
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5495ef3acb214113a133c8fbd43a5744
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06562854B2

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