Morpholine → 4-(4-Methoxyphenyl)morpholine

참여 물질

역할	이름	HCID	투입량
반응물	Morpholine	HCID 8083	—
반응물	4-Chloroanisole	HCID 12167	—
반응물	Sodium t-butoxide	HCID 23676156	—
생성물	4-(4-Methoxyphenyl)morpholine	HCID 389874	95%

반응 단계

According to the general procedure B, 4-chloroanisole (82 mg, 0.55 mmol) reacted with morpholine (46 mg, 0.53 mmol) using 1 mol % of catalyst and sodium tert-butoxide (63 mg, 0.60 mmol) at 70° C. for 27 h to give the title compound (97 mg, 95%) as a solid: 1H-NMR (400 MHz, CDCl3): δ 6.92-6.85 (m, 4H), 3.87 (t, 4H, J=4.8 Hz), 3.78 (s, 3H), 3.07 (t, 4H, J=4.8 Hz). 13C{1H}-NMR (100 MHz, CDCl3): δ 153.92, 145.60, 117.77, 114.47, 67.00, 55.52, 50.78. GC/MS(EI); m/z 193 (M+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06562989B2
출처 데이터셋	uspto-grants-2003_05
ORD ID	ord-69c9313189f34bbda831a61107ff6db8
출처 메모	uspto-grants-2003_05