Benzylamine → N-Benzyl-4-methoxyaniline

참여 물질

역할	이름	HCID	투입량
반응물	Benzylamine	HCID 7504	—
반응물	4-Chloroanisole	HCID 12167	—
반응물	Sodium t-butoxide	HCID 23676156	—
촉매	(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium	HCID 6505921	—
용매	Toluene	HCID 1140	—
생성물	N-Benzyl-4-methoxyaniline	HCID 519413	93%

반응 단계

According to the general procedure A, 4-chloroanisole (73 mg, 0.51 mmol) reacted with benzylamine (68 mg, 0.63 mmol) using 1 mol % of Pd(dba)2, 2 mol % of Ph5FcP(t-Bu)2, and sodium tert-butoxide (60 mg, 0.63 mmol) in toluene at 100° C. for 4 h to give the title compound (100 mg, 93%) as a solid: 1H-NMR (500 MHz, CDCl3): δ 6.63 (d, 2H, J=8.84 Hz), 6.81 (d, 2H, J=8.83 Hz), 7.41-7.35 (m, 4H), 7.30 (t, 1H, J=7.08 and 7.03 Hz), 4.31 (s, 2H), 3.77 (s, 3H). 13C{1H}-NMR (125 MHz, CDCl3): δ 152.18, 142.42, 139.66, 128.56, 127.52, 127.14, 114.89, 114.09, 55.78, 49.23. GC/MS(EI): m/z 213 (M+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06562989B2
출처 데이터셋	uspto-grants-2003_05
ORD ID	ord-102888443f3045c084418ea405022f1e
출처 메모	uspto-grants-2003_05