참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Butylboronic Acid | HCID 20479 | — |
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 1-Bromo-4-tert-butylbenzene | HCID 77595 | — |
| 촉매 | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-Tert-butyl-1-n-butylbenzene | HCID 524168 | 92% |
반응 단계
A 4 mL vial was charged with 4-tert-butylbromobenzene (213 mg, 1.00 mmol), Pd(dba)2 (5.8 mg, 0.01 mmol, 1 mol %), Ph5FcP(t-Bu)2 (14.2 mg, 0.02 mmol, 2 mol %), K3PO4 (430 mg, 2.02 mmol, powdered) and n-butylboronic acid (124 mg, 1.21 mmol). Anhydrous toluene (2 mL) and a stirring bar were added, and the vial was then sealed with a cap containing a PTFE septum and removed from the drybox. The reaction mixture was stirred at 100° C. for 2.5 h. After the starting aryl halide was consumed as determined by GC, the reaction solution was cooled to room temperature. The reaction solution was then adsorbed onto silica gel directly, and the product was isolated by eluting with ethyl acetate/hexanes to give 175 mg (92%) of 4-tert-butyl-1-n-butylbenzene as colorless oil. Kugelrohl distillation was used for further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06562989B2 |
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| 출처 데이터셋 | uspto-grants-2003_05 |
|---|
| ORD ID | ord-801f7212aa3d403ea1696374d672f356 |
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| 출처 메모 | uspto-grants-2003_05 |
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