Dimethylmaleic anhydride → 2,3-Dimethyl-N-(1-aminocarbonyl-1,2-dimethyl-propyl)maleic acid monoamide

HRID 4128

반응식

HRID 4128 반응식
[CH3:1][C:2]1=[C:3]([CH3:9])[C:4]([O:6][C:7]1=[O:8])=[O:5].[NH2:10][C:11]([CH3:18])([CH:15]([CH3:17])[CH3:16])[C:12]([NH2:14])=[O:13]>C(Cl)Cl>[CH3:9]/[C:3](=[C:2](\[CH3:1])/[C:7]([OH:6])=[O:8])/[C:4]([NH:10][C:11]([C:12]([NH2:14])=[O:13])([CH3:18])[CH:15]([CH3:17])[CH3:16])=[O:5]

참가 물질

4

반응물 2

HCID 13010Dimethylmaleic anhydrideHCID 97937732-Amino-2,3-dimethylbutanamide

생성물 1

HCID 138831692,3-Dimethyl-N-(1-aminocarbonyl-1,2-dimethyl-propyl)maleic acid monoamide수율 96.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 46 g of dimethylmaleic acid anhydride, 48 g of 2-amino-2,3-dimethylbutyric acid amide and 70 ml of methylene chloride was heated at its boiling point for 15 minutes. After some of the solvent had been distilled off, the residual mixture was stirred with 300 ml of diethyl ether, and the product precipitated thereby was suction-filtered off. The desired compound (II) (90 g; 96%) was isolated as a crystalline solid, melting point 70°-72° C.

후처리

  1. temperaturewas heated at its boiling point for 15 minutes
  2. distillationAfter some of the solvent had been distilled off
  3. customthe product precipitated
  4. filtrationthereby was suction-filtered off

출처 및 근거

ORD 기록
ord-aa9ed74e9a0d49428bacce5162b0c162
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723989

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