Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Bromo-2,6-dichlorobenzene → 2,6-Dichloro-2'-methyl-1,1'-biphenyl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Bromo-2,6-dichlorobenzene | HCID 29568 | — |
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 2-Methylphenyl boronic acid | HCID 2733267 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2,6-Dichloro-2'-methyl-1,1'-biphenyl | HCID 14345447 | 92.8% |
반응 단계
1-Bromo-2,6-dichlorobenzene (90 mg,-0.40 mmol) reacted with 2-methylphenylboronic acid (82 mg, 0.60 mmol) using 2/4 mol % of Pd(dba)2/Ph5FcP(t-Bu)2 and K3PO4 (254 mg, 1.20 mmol) in toluene at 100° C. to give the title compound (88 mg, 76%): 1H-NMR (400 MHz, CDCl3): δ 8.07 (d, 2H, J=8.07 Hz), 7.28-7.18 (m, 3H), 7.15 (t, 1H, J=8.13 Hz), 7.00 (d, 1H, J=7.25 Hz), 1.99 (s, 3H). 13C{1H}-NMR (125 MHz, CDCl3): δ 139.23, 136.91, 136.16, 135.09, 129.90, 129.04, 129.01, 128.39, 127.88, 125.81, 19.30. GC/MS(EI): (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06562989B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-b80c3729f67c41f0a0dd3eb1a2ecdae9 |
| 출처 메모 | uspto-grants-2003_05 |