Tert-butyl 4-hydroxypiperidine-1-carboxylate → 4-(Pyrazin-2-ylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester

반응식

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11](O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[SH:15][C:16]1[CH:21]=[N:20][CH:19]=[CH:18][N:17]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([S:15][C:16]2[CH:21]=[N:20][CH:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

반응물 2

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

HCID 178527737HCID 178527737, 화합물

생성물 1

HCID 185386084-(Pyrazin-2-ylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester

실험 절차

By a similar manner to Reference Example 35, 1-tert-butoxycarbonyl-4-hydroxypiperidine (1.01 g, 5.0 mmol) was reacted with mercaptopyrazine (0.67 g, 6.0 mmol) to give the titled compound as pale yellow oily substance (1.26 g, 85%).

출처 및 근거

ORD 기록: ord-ea59a934baf8491a861043e0ca5e19af
출처 데이터셋: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06562978B1

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