Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Benzyl 4-methylidenepyrazolidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Benzyl tert-butyl 4-methylidenepyrazolidine-1,2-dicarboxylate | HCID 12970152 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Benzyl 4-methylidenepyrazolidine-1-carboxylate | HCID 12970153 | 97% |
반응 단계
To a solution of crude 4-methylenepyrazolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester, 1, (30 g) in methanol (300 mL) is added thionyl chloride dropwise at 0° C. The reaction is warmed to room temperature and stirred an additional 18 hours. Concentration of the reaction in vacuo affords a yellow oil which crystallizes upon standing to provide 23 g (97% yield) of the desired product as the HCl salt.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06566357B1 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-af422b1a592b4583b747bf5daf50f0f5 |
| 출처 메모 | uspto-grants-2003_05 |