Ethyl Bromide → 2-Ethoxy-4-methoxybenzonitrile

HRID 413075노트

반응식

HRID 413075 반응식
[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][CH3:20]>CC(C)=O>[CH2:19]([O:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH3:20]

참가 물질

5

반응물 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 114236802-Hydroxy-4-methoxybenzonitrile

생성물 1

HCID 218969052-Ethoxy-4-methoxybenzonitrile

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

30.0 g (201 mmol) of 2-hydroxy-4-methoxybenzonitrile are refluxed with 83.4 g of potassium carbonate (603 mmol) and 32.88 g (301 mmol) of bromoethane in 550 ml of acetone for 18 hours. After filtration, the solvent is removed under reduced pressure and the residue is purified by silica gel chromatography (cyclohexane:ethyl acetate=10:1): 35.9 g of an oil Rf=0.37 (cyclohexane:ethyl acetate=3:1)

후처리

  1. filtrationAfter filtration
  2. customthe solvent is removed under reduced pressure
  3. customthe residue is purified by silica gel chromatography (cyclohexane:ethyl acetate=10:1)

출처 및 근거

ORD 기록
ord-25378587c55c483c9fcfd0b86c0e7eb0
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06566360B1

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