(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid → 4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-thiophene-2-carbonitrile

참여 물질

역할	이름	HCID	투입량
반응물	(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid	HCID 10987806	—
반응물	4-Bromothiophene-2-carbonitrile	HCID 14292355	—
용매	Water	HCID 962	—
생성물	4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-thiophene-2-carbonitrile	HCID 9943699	—

반응 단계

Prepared from (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid and 4-bromo-2-thiophenecarbonitrile according to Procedure B. Yellowish solid: mp 230-231° C. (decomposed); 1H-NMR (CDCl3) δ8.32 (s, 1H, D2O exchangeable), 7.83 (d, 1H, J=1.5 Hz), 7.61 (d, 1H, J=1.4 Hz), 7.43 (dd, 1H, J=8.2, 1.9 Hz), 7.29 (d, 1H, J=1.8 Hz), 6.85 (d, 1H, J'8.2 Hz), 1.78 (s, 6H); MS (EI) m/z 283(M−H, 100%). Anal. Calc. For C15H12N2O2S.0.2 H2O: C, 62.57, H, 4.34, N, 9.73. Found: C, 62.48, H, 4.31, N, 9.64.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06566358B2
출처 데이터셋	uspto-grants-2003_05
ORD ID	ord-d43e0b75547447c7a52e2fb164e853c6
출처 메모	uspto-grants-2003_05