1,1'-Carbonyldiimidazole → HCID 15484057, 화합물
반응식
[F:1][C:2]([F:15])([F:14])[S:3]([C:6]1[CH:7]=[C:8]([NH2:13])[C:9]([NH2:12])=[CH:10][CH:11]=1)(=[O:5])=[O:4].C1N=CN([C:21](N2C=NC=C2)=[O:22])C=1>CC#N>[F:15][C:2]([F:14])([F:1])[S:3]([C:6]1[CH:11]=[CH:10][C:9]2[NH:12][C:21](=[O:22])[NH:13][C:8]=2[CH:7]=1)(=[O:4])=[O:5]참가 물질
4
실험 절차
Reflux 4-trifluoromethylsulfonyl-benzene-1,2-diamine (420 mg) and CDI (284 mg) for 16 hours in CH3CN (30 mL). Evaporate the solvent in vacuo. Purify by flash chromatography (1:1 hexanes/EtOAc) to obtain 5-trifluoromethylsulfonyl-1,3-dihydro-benzimidazol-2-one.
후처리
- customEvaporate the solvent in vacuo
- customPurify by flash chromatography (1:1 hexanes/EtOAc)
출처 및 근거
- ORD 기록
- ord-b8635cf9297b484db8243aa3db62d5d2
- 출처 데이터셋
- uspto-grants-2003_05
- 특허 번호
- US06566367B2
반응 노트
불러오는 중…