참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | HCID 178418306 | HCID 178418306 | — |
| 반응물 | HCID 178489586 | HCID 178489586 | — |
| 용매 | Pentane | HCID 8003 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 58238629 | HCID 58238629 | 93% |
반응 단계
To a solution of 1.27 g (6.00 mmol) of 9 in 40 mL of THF, 4.20 mL (6.30 mmol) of 1.5 M tBuLi in pentane was added with vigorous stirring at −80° C. The mixture was slowly warmed to room temperature, and then 2 mL of water was added. The resulting mixture was evaporated to dryness. The product was isolated by flash chromatography on silica gel 60 (40-63 um, eluent: from hexanes to hexanes-diethyl ether=40:1, vol.) to yield 1.50 g (93%) of B1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08530593B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-ab640f051e334e1a82ee542ac64a9fd8 |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
