Dichloromethane → N,N-Bis(2-chloroethyl)-N'-phenylcarbamimidic acid

HRID 413275노트

반응식

HRID 413275 반응식
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][N:8]([CH2:18]CO)[C:9]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:10].Cl[CH2:22][Cl:23]>>[Cl:3][CH2:6][CH2:7][N:8]([CH2:18][CH2:22][Cl:23])[C:9]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:10]

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 22390756HCID 22390756, 화합물

생성물 1

HCID 247712N,N-Bis(2-chloroethyl)-N'-phenylcarbamimidic acid

실험 절차

26.44 ml of thionyl chloride are added, at 0° C., to a solution of 0.173 mol of the product obtained in Step 1 in 100 ml of dichloromethane. After reacting for 4 hours at reflux and then for 12 hours at ambient temperature, the reaction mixture is concentrated under reduced pressure.

후처리

  1. temperatureat reflux
  2. waitfor 12 hours at ambient temperature
  3. concentrationthe reaction mixture is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7795bb81d61a4f37b1b3c8f85dca6f17
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06566364B2

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