Benzyl Bromide → 1-benzyl-1H-pyrazole-3-carbaldehyde
반응식
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:9]1[CH:13]=[CH:12][C:11]([CH:14]=[O:15])=[N:10]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:1]([N:9]1[CH:13]=[CH:12][C:11]([CH:14]=[O:15])=[N:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
5
실험 절차
To a solution of benzyl bromide (0.29 g) in N,N-dimethylformamide (9 ml) was added 1H-pyrazole-3-carboxaldehyde (0.15 g) and potassium carbonate (0.24 g). The mixture was stirred at room temperature for 24 hours, silica gel was added, the solvent removed by evaporation and the crude material purified by chromatography (isohexane:ether, 2:1) to give the product as an oil (0.18 g).
후처리
- additionsilica gel was added
- customthe solvent removed by evaporation
- customthe crude material purified by chromatography (isohexane:ether, 2:1)
출처 및 근거
- ORD 기록
- ord-6d33378c29d04b489b7fbd4671e4aa97
- 출처 데이터셋
- uspto-grants-2003_05
- 특허 번호
- US06566376B1
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