Potassium Hydroxide → 5-[1-(3-Methoxy-phenyl)-2-oxo-cyclohexyl]-pentanoic acid

HRID 413426

반응식

HRID 413426 반응식
[OH-].[K+].C([O:5][C:6](=[O:26])[CH2:7][CH2:8][CH2:9][CH2:10][C:11]1([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=2)[CH2:16][CH2:15][CH2:14][CH2:13][C:12]1=[O:17])C>CCO>[CH3:25][O:24][C:20]1[CH:19]=[C:18]([C:11]2([CH2:10][CH2:9][CH2:8][CH2:7][C:6]([OH:26])=[O:5])[CH2:16][CH2:15][CH2:14][CH2:13][C:12]2=[O:17])[CH:23]=[CH:22][CH:21]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 700297965-[1-(3-Methoxy-phenyl)-2-oxo-cyclohexyl]-pentanoic acid ethyl ester

생성물 1

HCID 185331945-[1-(3-Methoxy-phenyl)-2-oxo-cyclohexyl]-pentanoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Solid KOH (0.090 g, 1.4 mmol) was added to a solution of the ester from Step A (0.132 g, 0.38 mmol) in EtOH (5 mL). After stirring at ambient temperature for 48 hr, the reaction mixture was partitioned between EtOAc (50 mL) and H2O (100 mL), the aqueous layer acidified, then extracted with EtOAc (2×100 mL), the organic layer washed with H2O (50 mL), dried (Na2SO4), filtered, and concentrated to dryness to give the title compound. Mp 89-91° C. MS 318.

후처리

  1. customthe reaction mixture was partitioned between EtOAc (50 mL) and H2O (100 mL)
  2. extractionextracted with EtOAc (2×100 mL)
  3. washthe organic layer washed with H2O (50 mL)
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-1b6bfe12da7f4683afa11fcac00accc3
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06566385B2

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