Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosgene → 10-Methoxy-5H-dibenz(b,f)azepine-5-carbonyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosgene | HCID 6371 | — |
| 반응물 | Oxcarbazepine | HCID 34312 | — |
| 반응물 | 10-Methoxyiminostilbene | HCID 78424 | — |
| 생성물 | 10-Methoxy-5H-dibenz(b,f)azepine-5-carbonyl chloride | HCID 16050081 | — |
반응 단계
U.S. Pat. No. 3,642,775 assigned to Ciba-Geigy Corporation, claims Oxcarbazepine specifically and discloses the process for the preparation of Oxcarbazepine, wherein 10-methoxy-5H-dibenz[b,f]azepine is reacted with phosgene gas to give 10-methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride and ammonolysis of the resultant compound to give the amide followed by hydrolysis to give Oxcarbazepine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08530647B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-60bf5f9e5dc041ce8cc30181f4c613f9 |
| 출처 메모 | uspto-grants-2013_09 |