Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Mandelic Acid → 10-methoxy-5H-dibenz(b,f)azepine-5-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Mandelic Acid | HCID 1292 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 10-Methoxyiminostilbene | HCID 78424 | — |
| 반응물 | Sodium Cyanate | HCID 517096 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 10-methoxy-5H-dibenz(b,f)azepine-5-carboxamide | HCID 120031 | 83.8% |
반응 단계
A suspension of 10 g of 10-methoxyiminostilbene in 200 ml toluene was treated with 20 g of sodium cyanate and 39 g of mandelic acid and was heated to reflux for about 10 hrs. The reaction mixture was cooled to room temperature and charged with sodium hydroxide solution and maintained for 19 hrs. The resulting suspension was filtered, washed with water and dried to give 10 g of 10-methoxy carbamazepine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08530647B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-d481f292f5d5474a8f07a889c5a31c7f |
| 출처 메모 | uspto-grants-2013_09 |