Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Mandelic Acid → Carbamazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Mandelic Acid | HCID 1292 | — |
| 반응물 | Dibenz(b,f)azepine | HCID 9212 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Sodium Cyanate | HCID 517096 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Carbamazepine | HCID 2554 | 90% |
반응 단계
A suspension of 10 g of iminostilbene in 100 ml toluene was treated with 20.2 g of sodium cyanate and 27.5 g of mandelic acid and was heated to reflux for about 10 hrs. The reaction mixture was cooled to room temperature and charged with sodium hydroxide solution and maintained for 8 hrs. The resulting suspension was filtered, washed with water and dried to give 11 g of carbamazepine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08530647B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-9156a4b6f0a14fffb3d533decc5b9669 |
| 출처 메모 | uspto-grants-2013_09 |