Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyanogen Bromide → Quinazolin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyanogen Bromide | HCID 10476 | — |
| 반응물 | Hydrate;hydrochloride | HCID 21885828 | — |
| 반응물 | ethyl-N-(6-amino-2,3-dichlorobenzyl)glycine | HCID 67080112 | — |
| 반응물 | Anagrelide | HCID 135409400 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Quinazolin-2-amine | HCID 178508286 | — |
반응 단계
Commercially, as discussed in U.S. Pat. No. 5,801,245, and as shown in FIG. 1, anagrelide has been prepared as the hydrochloride monohydrate (compound IV) from the intermediate, ethyl-N-(6-amino-2,3-dichlorobenzyl)glycine (compound I) either by reaction with cyanogen bromide in hot alcoholic solution, or, preferentially, by reaction with cyanogen bromide in an aprotic solvent such as toluene to give the iminoquinazoline intermediate (compound II), which is isolated and then reacted with a base in a hot solution of alcohol to form anagrelide base (compound III).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08530651B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-16c12e29c27c4e31ace7baeccc73080c |
| 출처 메모 | uspto-grants-2013_09 |