Ethyl 4-sulfanylbutanoate → Ethyl 4-(4-bromo-2-formylphenylthio)butyrate

HRID 413588노트

반응식

HRID 413588 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[CH:7]=[O:8].[SH:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([S:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:6]([CH:7]=[O:8])[CH:9]=1

참가 물질

3

반응물 2

HCID 271824Ethyl 4-sulfanylbutanoateHCID 7363275-Bromo-2-fluorobenzaldehyde

생성물 1

HCID 18533381Ethyl 4-(4-bromo-2-formylphenylthio)butyrate수율 78%

실험 절차

Ethyl 4-(4-bromo-2-formylphenylthio)butyrate was synthesized from 5-bromo-2-fluorobenzaldehyde and ethyl 4-mercaptobutyrate in the same manner as Example 2. After column chromatography, crystallization from hexane/isopropyl ether yielded ethyl 4-(4-bromo-2-formylphenylthio)butyrate (Yield 78%) as yellow crystals.

후처리

  1. customAfter column chromatography, crystallization from hexane/isopropyl ether

출처 및 근거

ORD 기록
ord-fc31491f255a44a8bf42c367ec655516
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06566535B1

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