Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 3,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 2-Hydrazinopyridine | HCID 78645 | — |
| 반응물 | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 9856256 | — |
반응 단계
Similar to Example 1, 2-pyridylhydrazine (7.5 mmol, 0.8 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (7.5 mmol, 1.3 g) were mixed in a solution of 50% pyridine in ethanol, then heated under reflux. The solvents were removed under vacuum and the residue purified over silica. The named product crystallized upon standing (m.p. 49° C.-50° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06569885B1 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-d01bbee3b31c41f8a1f6a7be019434ad |
| 출처 메모 | uspto-grants-2003_05 |