3,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester → 1-(3-Aminophenyl)-3,5-dimethyl-1h-pyrazole-4-carboxylic acid ethyl ester

HRID 413764

반응식

HRID 413764 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:21])=[N:8][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-])=O)[CH:13]=2)[C:10]=1[CH3:11])=[O:5])[CH3:2].[H][H]>C(O)C.[Pd]>[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:21])=[N:8][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([NH2:18])[CH:13]=2)[C:10]=1[CH3:11])=[O:5])[CH3:2]

참가 물질

5

반응물 2

HCID 6569693,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 98138381-(3-Aminophenyl)-3,5-dimethyl-1h-pyrazole-4-carboxylic acid ethyl ester

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The compound of Example 2 (1.8 g,) was dissolved in ethanol then 0.2 g 5% Pd/C was added to the solution. The mixture was treated with hydrogen gas at 45 psi. Upon completion of the reaction, the solution was filtered through Celite, and the filtrate concentrated under vacuum. The named product slowly crystallized upon standing (m.p. 93° C.-95° C.).

후처리

  1. customUpon completion of the reaction
  2. filtrationthe solution was filtered through Celite
  3. concentrationthe filtrate concentrated under vacuum
  4. customThe named product slowly crystallized

출처 및 근거

ORD 기록
ord-a0f098accb9a466ba627a796594f936d
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06569885B1

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