Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → 1-(3-Chlorophenyl)-2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | 3-Chloroaniline | HCID 7932 | — |
| 반응물 | Ethyl 2-acetyl-4-oxo-4-phenylbutanoate | HCID 312893 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-(3-Chlorophenyl)-2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester | HCID 9881056 | — |
반응 단계
m-Chloroaniline (5 mmol, 0.6 g), 3-oxo-2-(2-oxo-2-phenyl-ethyl)-butyric acid ethyl ester (5 mmol, 1.2 g), and tosic acid (0.1 g) were combined in ethanol, then heated under reflux. Upon completion of the reaction, the crude solid was recrystallized from ethanol to afford the desired product (m.p. 99.6° C.-100.5° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06569890B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-1a92e81434ad4c28a34a1392b95e7290 |
| 출처 메모 | uspto-grants-2003_05 |