p-Toluenesulfonic acid → 5-Methyl-1-(3-nitrobenzyl)-2-phenyl-1h-pyrrole-3-carboxylic acid ethyl ester

HRID 413914

반응식

HRID 413914 반응식
Cl.[N+:2]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][NH2:9])([O-:4])=[O:3].C(=O)(O)[O-].[Na+].[N+](C1C=C(C=CC=1)CN)([O-])=O.[CH2:29]([O:31][C:32](=[O:46])[CH:33]([C:38](=O)[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[CH2:34][C:35](=O)[CH3:36])[CH3:30].CC1C=CC(S(O)(=O)=O)=CC=1>C(O)C>[CH2:29]([O:31][C:32]([C:33]1[CH:34]=[C:35]([CH3:36])[N:9]([CH2:8][C:7]2[CH:10]=[CH:11][CH:12]=[C:5]([N+:2]([O-:4])=[O:3])[CH:6]=2)[C:38]=1[C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1)=[O:46])[CH3:30]

참가 물질

7

반응물 5

HCID 6101p-Toluenesulfonic acidHCID 1227223-NitrobenzylamineHCID 516892Sodium BicarbonateHCID 2724030Benzenemethanamine, 3-nitro-, hydrochloride (1:1)HCID 14689358Ethyl 2-benzoyl-4-oxopentanoate

생성물 1

HCID 101093645-Methyl-1-(3-nitrobenzyl)-2-phenyl-1h-pyrrole-3-carboxylic acid ethyl ester

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

m-Nitrobenzylamine hydrochloride (3 g) was suspended in an aqueous solution of saturated sodium bicarbonate (30 mL), and extracted with chloroform. The organic layer was dried over MGSO4, the solids saturated and solvents removed under vacuum to yield the free base. The m-nitrobenzylamine (5 mmol, 0.8 g) prepared above, 2-benzoyl-4-oxo-pentanoic acid ethyl ester (5 mmol, 1.2 g), and tosic acid were combined in ethanol, then heated under reflux. The resulting residue was purified over silica gel to yield the named product, 1H-NMR (CDCl3, ppm): 1.10 t (3H), 3.16 s (3H), 4.08 q (2H), 5.04 s (2H), 6.55 s (1H), 7.07-7.53 bm (7H), 7.72 bs (1H), 8.04 bd (1H).

후처리

  1. extractionextracted with chloroform
  2. customThe organic layer was dried over MGSO4
  3. customthe solids saturated and solvents removed under vacuum
  4. customto yield the free base
  5. temperatureheated
  6. temperatureunder reflux
  7. customThe resulting residue was purified over silica gel
  8. customto yield the named product, 1H-NMR (CDCl3, ppm): 1.10 t (3H), 3.16 s (3H), 4.08 q (2H), 5.04 s (2H), 6.55 s (1H), 7.07-7.53 bm (7H), 7.72 bs (1H), 8.04 bd (1H)

출처 및 근거

ORD 기록
ord-c9efedc6a36749e2a470569d83e999da
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06569890B2

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