Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N-(3-chloropropyl)-4-nitrobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Nitrobenzoyl chloride | HCID 8502 | — |
| 반응물 | 3-Chloropropylamine | HCID 84629 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(3-chloropropyl)-4-nitrobenzamide | HCID 3421653 | 91% |
반응 단계
A solution of 6.43 g (49 mmol) 3chloropropylamine and 13.6 ml (98 mmol) triethylamine in 220 ml methylene chloride was cooled by an ice bath and 9 g (48.5 mmol) 4-nitrobenzoyl chloride were added fractionwise. After one hour stirring at room temperature the organic phase was washed twice with water, dried over MgSO4 and concentrated in vacuo to afford 10.68 g (91%) of beige crystals. 1H NMR was consistent with the desired structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06570037B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-05c21b4c0a3e4e1bb8ccb86f776fa136 |
| 출처 메모 | uspto-grants-2003_05 |