Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-Pyridinecarboxylic acid, 2-[(phenylmethyl)thio]-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Benzyl Chloride | HCID 7503 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | HCID 178524460 | HCID 178524460 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Pyridinecarboxylic acid, 2-[(phenylmethyl)thio]- | HCID 757779 | 97.1% |
반응 단계
200 parts 2-mercaptonicotinic acid, 970 parts of water, 215 parts of 50% NaOH, and 164 parts of benzyl chloride were combined and the resulting solution was refluxed for 2 hours. After dilution with 2580 parts of water, the solution was acidified with 207 parts of 36% HCl. The resulting slurry was cooled and filtered. The wet cake was washed with water and dried to give 307 parts (97.1%) of 2-(phenylmethylthio)-3-pyridinecarboxylic acid, m.p. 190°-193° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04789393 |
| 출처 데이터셋 | uspto-grants-1988_12 |
| ORD ID | ord-efa42f0a24d648f6a6467fcab5f00161 |
| 출처 메모 | uspto-grants-1988_12 |