Hydrogen Peroxide → 3-Chloro-2-pyridinesulfonamide-1-oxide

HRID 414036노트

반응식

HRID 414036 반응식
[Cl:1][C:2]1[C:3]([S:8]([NH2:11])(=[O:10])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.[OH:12]O>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[N+:4]([O-:12])[C:3]=1[S:8]([NH2:11])(=[O:9])=[O:10]

참가 물질

4

반응물 2

HCID 784Hydrogen PeroxideHCID 146531913-Chloropyridine-2-sulfonamide

생성물 1

HCID 146531923-Chloro-2-pyridinesulfonamide-1-oxide

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

To a stirring solution of 3-chloro-2-pyridinesulfonamide (2.5 g, 13.0 mmol) in 35 mL of trifluoroacetic acid was added 30% H2O2 (1.2 g, 35.1 mmol). The solution was concentrated to ~15 mL, diluted with ethyl acetate, washed twice with brine, dried and concentrated. The resulting solid was flash chromatographed with EtOAc to afford the desired product, m.p. 195°-197° C.

후처리

  1. concentrationThe solution was concentrated to ~15 mL
  2. additiondiluted with ethyl acetate
  3. washwashed twice with brine
  4. customdried
  5. concentrationconcentrated
  6. customchromatographed with EtOAc

출처 및 근거

ORD 기록
ord-f666cba1e83b4b27a01b856d53dc4028
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04789465

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