2-(Azidomethyl)-1,3-difluorobenzene → 1-(2,6-difluorobenzyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide
반응식
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[C:3]=1[CH2:4][N:5]=[N+:6]=[N-:7].[CH2:13]([C:17]([NH2:19])=[O:18])[C:14]#[C:15]C>O1CCOCC1>[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[C:3]=1[CH2:4][N:5]1[C:14]([CH3:15])=[C:13]([C:17]([NH2:19])=[O:18])[N:7]=[N:6]1참가 물질
4
실험 절차
16.9 g (0.1 mole) of 2,6-difluorobenzyl azide and 8.3 g (0.1 mole) of but-2-ynecarboxamide are heated in 20 ml of dioxane for 16 hours to 100° C. After removing the dioxane by evaporation, the desired isomer is separated by column chromatography, to give 1-(2,6-difluorobenzyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide with a melting point of 208°-210° C. (recrystallisation from methanol).
후처리
- customAfter removing the dioxane
- customby evaporation
- customthe desired isomer is separated by column chromatography
출처 및 근거
- ORD 기록
- ord-041fba32ce2c4336856fe3d1dd668d44
- 출처 데이터셋
- uspto-grants-1988_12
- 특허 번호
- US04789680
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