Acetic Acid → (5-Benzylidene-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)acetic acid

HRID 414247

반응식

HRID 414247 반응식
[C:1]([CH2:4][N:5]1[C:9](=[O:10])[CH2:8][S:7][C:6]1=[S:11])([OH:3])=[O:2].C([O-])(=O)C.[Na+].C(O)(=O)C.[CH:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>O>[C:1]([CH2:4][N:5]1[C:9](=[O:10])[C:8](=[CH:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[S:7][C:6]1=[S:11])([OH:3])=[O:2]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 240BenzaldehydeHCID 797933-Thiazolidineacetic acid, 4-oxo-2-thioxo-HCID 517045Sodium Acetate

생성물 1

HCID 2769989(5-Benzylidene-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)acetic acid수율 50.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 955 mg of 3-carboxymethylrhodanine, 516 mg of sodium acetate, 10 ml of acetic acid and 637 mg of benzaldehyde was heat-refluxed for 2 hours. To the reaction mixture was added 20 ml of water, and the precipitated crystals were filtered. The resulting crystals were recrystallized from ethanol to obtain 699 mg of the titled compound.

후처리

  1. temperaturewas heat-refluxed for 2 hours
  2. filtrationthe precipitated crystals were filtered
  3. customThe resulting crystals were recrystallized from ethanol

출처 및 근거

ORD 기록
ord-a444ec43631545029d9c04c48a253cdf
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04791126

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