Sulfuric Acid → 2,3-Dichloro-4,5-difluorobenzoic acid

HRID 414366노트

반응식

HRID 414366 반응식
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](N)=[O:5].S(=O)(=O)(O)[OH:15]>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([OH:15])=[O:5]

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 140963682,3-Dichloro-4,5-difluorobenzamide

생성물 1

HCID 139380362,3-Dichloro-4,5-difluorobenzoic acid

실험 절차

A mixture of 2,3-dichloro-4,5-difluorobenzamide (0.5 g) and 18N-sulfuric acid (2.5 ml) was stirred at 125° to 135° C. for 9 hours, and then poured into ice water. After standing overnight, the resulting precipitate was collected by filtration and recrystallized from hexane-benzene to give the title compound (0.3 g) as colorless prisms.

후처리

  1. waitAfter standing overnight
  2. filtrationthe resulting precipitate was collected by filtration
  3. customrecrystallized from hexane-benzene

출처 및 근거

ORD 기록
ord-bca41dfd152b4789a29d2a3ac59a5c4f
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04791225

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