Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 1-(Chloromethyl)-4-(methylthio)benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | [4-(Methylsulfanyl)phenyl]methanol | HCID 592968 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 1-(Chloromethyl)-4-(methylthio)benzene | HCID 70128 | — |
반응 단계
To a stirred solution of 154 g (1 mol) of 4-methylmercaptobenzyl alcohol in 1 liter of dry benzene was added dropwise 80 mL 1.1 mol) of thionyl chloride. The mixture immediately turned blue. After the addition of the thionyl chloride was completed, the mixture was heated at reflux for 2 hours. After cooling the benzene and excess thionyl chloride were distilled at ambient pressure. The product was distilled in vacuo at 105° C. (0.5 mm), to yield 160 g (93%) of water clear liquid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04792208 |
| 출처 데이터셋 | uspto-grants-1988_12 |
| ORD ID | ord-6881de694ca04e9bad722370699530b7 |
| 출처 메모 | uspto-grants-1988_12 |