Thionyl Chloride → 1-(Chloromethyl)-4-(methylthio)benzene

HRID 414429

반응식

HRID 414429 반응식
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]O)=[CH:5][CH:4]=1.S(Cl)([Cl:13])=O>C1C=CC=CC=1>[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][Cl:13])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 24386Thionyl Chloride3회HCID 592968[4-(Methylsulfanyl)phenyl]methanol

생성물 1

HCID 701281-(Chloromethyl)-4-(methylthio)benzene

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

To a stirred solution of 154 g (1 mol) of 4-methylmercaptobenzyl alcohol in 1 liter of dry benzene was added dropwise 80 mL 1.1 mol) of thionyl chloride. The mixture immediately turned blue. After the addition of the thionyl chloride was completed, the mixture was heated at reflux for 2 hours. After cooling the benzene and excess thionyl chloride were distilled at ambient pressure. The product was distilled in vacuo at 105° C. (0.5 mm), to yield 160 g (93%) of water clear liquid.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 2 hours
  3. distillationwere distilled at ambient pressure
  4. distillationThe product was distilled in vacuo at 105° C. (0.5 mm)
  5. customto yield 160 g (93%) of water clear liquid

출처 및 근거

ORD 기록
ord-6881de694ca04e9bad722370699530b7
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04792208

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