Acetone → HCID 53891928, 화합물

HRID 414524노트

반응식

HRID 414524 반응식
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([OH:10])[C:7]([NH:11][C:12](=[O:14])[CH3:13])=[C:6]([OH:15])[CH:5]=1.[CH2:17](Br)[CH:18]=[CH2:19].C(=O)([O-])[O-].[K+].[K+].[CH3:27][C:28]([CH3:30])=O>>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:5]=[C:6]([O:15][CH2:17][CH:18]=[CH2:19])[C:7]([NH:11][C:12](=[O:14])[CH3:13])=[C:8]([O:10][CH2:30][CH:28]=[CH2:27])[CH:9]=1

참가 물질

5

반응물 4

HCID 180AcetoneHCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 53960010Methyl 4-acetamido-3,5-dihydroxybenzoate

생성물 1

HCID 53891928HCID 53891928, 화합물

실험 절차

A mixture of 11.25 g. of 4-acetamido-3,5-dihydroxy-benzoic acid methyl ester, 12.1 g. of allyl bromide, 15 g. of dry potassium carbonate and 100 ml. of acetone was boiled and stirred on a reflux condenser for 17 hours. The acetone was removed by distillation. The residue was taken up in water/ethyl acetate. Thereafter, the organic phase separated, washed with water, dried and evaporated. Afters recrystallization from ethyl acetate/petroleum ether, there was obtained 4-acetamido-3,5-diallyloxy-benzoic acid methyl ester having a melting point of 135°-137° C.

후처리

  1. additionA mixture of 11.25 g
  2. customThe acetone was removed by distillation
  3. customThereafter, the organic phase separated
  4. washwashed with water
  5. customdried
  6. customevaporated
  7. customAfters recrystallization from ethyl acetate/petroleum ether

출처 및 근거

ORD 기록
ord-e747730518724c489f87cc1f6cfc44de
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04792557

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